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(Chest. 1984;85:70S-73S.)
© 1984 American College of Chest Physicians

Mechanisms of Lung Injury in the Copper-Deficient Hamster Model of Emphysema

Norman T. Soskel M.D.1; Suetaro Watanabe M.D., Ph.D.1; and Lawrence B. Sandberg M.D., Ph.D.1

1 Departments of Internal Medicine and Pathology, University of Utah School of Medicine, and Salt Lake City Veterans Administration Hospital, Salt Lake City

1) Dietary copper-deficiency induces emphysema in hamsters.

2) Copper-deficiency-induced emphysema develops chronically and, therefore, the time course of its development mimics that of the human disease.

3) Mechanisms other than inhibition of lysyl oxidase-mediated cross-link formation may be involved in the pathogenesis of emphysema that develops in copper-deficient hamsters. These mechanisms may be similar to those involved in the pathogenesis of human emphysema.






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Copyright © 1984 by the American College of Chest Physicians.