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Chest, Vol 86, 736-740, Copyright © 1984 by American College of Chest Physicians

ARTICLES

Hemodynamic effects of isoxsuprine in cardiac failure

EG Gozo Jr and RB Yebes

Isoxsuprine, a peripheral arteriolar vasodilator, was given to 12 patients with congestive heart failure. Cardiac index increased up to 31 percent; pulmonary artery wedge pressure fell by as much as 33 percent; mean arterial pressure fell by 17 percent; mean pulmonary artery pressure fell by 29 percent; systemic pulmonary vascular resistance fell by 37 percent; and pulmonary vascular resistance fell by 33 percent. All patients showed clinical improvement in the signs and symptoms of congestive heart failure during the three-hour observation period. This initial report documents the short-term salutary effects of isoxsuprine in congestive heart failure. The long- term efficacy of the drug remains to be evaluated.




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Copyright © 1984 by the American College of Chest Physicians.