Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fourrier, F.
Right arrow Articles by Durocher, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fourrier, F.
Right arrow Articles by Durocher, A.

Chest, Vol 87, 191-195, Copyright © 1985 by American College of Chest Physicians

ARTICLES

Compared evolution of plasma fibronectin and angiotensin-converting enzyme levels in septic ARDS

F Fourrier, C Chopin, B Wallaert, C Mazurier, J Mangalaboyi and A Durocher

Serum angiotensin converting enzyme (serum ACE) levels and plasma fibronectin levels were measured daily in 46 septic patients during a ten day period. Thirty-eight patients developed ARDS; 28 survived (group 1), ten died (group 2), eight patients had no features of ARDS and survived (group 3). Sequential measurements of ACE and fibronectin levels were compared and plotted against indexes of respiratory impairment: PaO2 max Qs/Qt, static compliance and VD/VA ratio. These indexes were taken as criteria of weaning from controlled ventilation. During ARDS (groups 1 and 2), serum ACE levels decreased and were closely correlated with the severity of lung injury. Persistently decreased levels after eight days were consistent with continuing injury or lack of endothelial repair. On the other hand, plasma fibronectin levels increased throughout the study in survivors (group 1 and 3) and decreased in the group with fatal ARDS only (group 2). These results indicate that serum ACE levels might be a good index of endothelial injury and repair during ARDS and fibronectin a better index for evolution of sepsis and vital prognosis.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
R. P. Marshall, S. Webb, G. J. Bellingan, H. E. Montgomery, B. Chaudhari, R. J. McAnulty, S. E. Humphries, M. R. Hill, and G. J. Laurent
Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Is Associated with Susceptibility and Outcome in Acute Respiratory Distress Syndrome
Am. J. Respir. Crit. Care Med., September 1, 2002; 166(5): 646 - 650.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. P. MARSHALL, R. J. MCANULTY, and G. J. LAURENT
Angiotensin II Is Mitogenic for Human Lung Fibroblasts via Activation of the Type 1 Receptor
Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1999 - 2004.
[Abstract] [Full Text]

Home page
 Pharmacol. Rev.Home page
C. Caliezi, W. A. Wuillemin, S. Zeerleder, M. Redondo, B. Eisele, and C. E. Hack
C1-Esterase Inhibitor: An Anti-Inflammatory Agent and Its Potential Use in the Treatment of Diseases Other Than Hereditary Angioedema
Pharmacol. Rev., March 1, 2000; 52(1): 91 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
T. G. Vondracek and W. F. Stanaszek
The Pathophysiology of Asthma
Journal of Pharmacy Practice, June 1, 1997; 10(3): 176 - 185.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the American College of Chest Physicians.