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Chest, Vol 87, 223-226, Copyright © 1985 by American College of Chest Physicians

ARTICLES

Kinetics of diazepam, midazolam, and lorazepam in cigarette smokers

HR Ochs, DJ Greenblatt and M Knuchel

Ten otherwise healthy cigarette smokers (mean, 31 cigarettes per day), and ten nonsmoking control volunteers matched for age, weight, and sex received single intravenous doses of diazepam (5 to 10 mg), midazolam (5 mg), and lorazepam (2 mg) on three separate occasions. Kinetics of each benzodiazepine were determined from multiple serum concentrations measured after each dose. In non-smoking vs smoking subjects, there was no significant difference in mean clearance of diazepam (0.44 vs 0.47 ml/min/kg), midazolam (9.6 vs 7.1 ml/min/kg), or lorazepam (0.96 vs 1.08 ml/min/kg). Thus, differences in pharmacokinetics are unlikely to account for altered sensitivity to benzodiazepines that may occur in cigarette smokers.


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D. J. Greenblatt, B. L. Ehrenberg, K. E. Culm, J. M. Scavone, K. E. Corbett, H. L. Friedman, J. S. Harmatz, and R. I. Shader
Kinetics and EEG Effects of Midazolam during and after 1-Minute, 1-Hour, and 3-Hour Intravenous Infusions
J. Clin. Pharmacol., June 1, 2004; 44(6): 605 - 611.
[Abstract] [Full Text] [PDF]


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Copyright © 1985 by the American College of Chest Physicians.