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Chest, Vol 87, 386-391, Copyright © 1985 by American College of Chest Physicians

REVIEWS

Aspirin-sensitive asthma

IK Slepian, KP Mathews and JA McLean

Aspirin intolerance is particularly common in asthmatic patients who additionally have chronic rhinitis and/or nasal polyps. These individuals differ in several respects from patients who experience urticaria and/or angioedema after aspirin administration, and differing mechanisms may be involved. Data regarding the latter are indirect and incomplete, but suggest that ASA-sensitive asthma is most likely to be related in some manner to the capacity of ASA to inhibit cyclooxygenases, enhanced lipoxygenase metabolism perhaps playing a crucial role. Current research employing ASA "desensitization" may help to elucidate these enigmas.


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Copyright © 1985 by the American College of Chest Physicians.