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(Chest. 1985;87:158S-159S.)
© 1985 American College of Chest Physicians

Bronchial Hyporesponsiveness

Peter T. Macklem M.D.1

1 Meakins-Christie Laboratories, McGill University Clinic, Royal Victoria Hospital, Montreal, Quebec, Canada

1. Normal bronchial hyporesponsiveness may be more important to explain than asthmatic hyperresponsiveness, which is predictable from the active force-length relationship of bronchial smooth muscle.

2. In vitro isometric force measurements on bronchial smooth muscle may have little relevance to asthma.

3. Whether these conclusions are correct depends on whether bronchoconstriction is quasi-isotonic. We need the answer to this question.

4. Whatever the answer, in vivo responses to inhalational challenges depend on the change in length of bronchial smooth muscle cells. Therefore, investigation should focus on the factors which determine change in length rather than change in force.




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