Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peters, S. P.
Right arrow Articles by Lichtenstein, L. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Peters, S. P.
Right arrow Articles by Lichtenstein, L. M.
(Chest. 1985;87:162S-164S.)
© 1985 American College of Chest Physicians

In Vitro and In Vivo Model Systems for the Study of Allergic and Inflammatory Disorders in Man

Implications for the Pathogenesis of Asthma

Stephen P. Peters M.D., Ph.D.1; Robert M. Naclerio M.D.2; Alkis Togias M.D.3; Robert P. Schleimer Ph.D.3; Donald W. MacGlashan Jr. M.D., Ph.D.3; Anne Kagey-Sobotka Ph.D.3; N. Franklin Adkinson Jr. M.D.3; Philip S. Norman M.D.3; and Lawrence M. Lichtenstein M.D., Ph.D.3

1 Recipient of Clinical Investigator Award HL 01034 from the National, Lung and Blood Institute, Baltimore
2 Recipient of Teacher Development Investigator Award NS 00811 from the National Institute of Neurological and Communicative Disorders and Stroke
3 Johns Hopkins University School of Medicine, Department of Medicine, Divisions of Clinical Immunology and Respiratory Medicine at The Good Samaritan Hospital, Baltimore

The IgE-mediated release of inflammatory substances from mast cells and basophils in vitro and, more recently, in vivo has proved to be a convenient model for studying mechanisms thought important in acute allergic reactions. The fact that IgE-mediated stimuli can initiate an immediate inflammatory response which can be manifest many hours after allergen exposure and that other triggers, including physical stimuli, can cause apparent mast cell activation suggests that these processes may be of general importance. Elucidating which cells and which chemical mediators play predominant roles in these reactions is a major challenge for the years ahead.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the American College of Chest Physicians.