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Chest, Vol 87, 735-739, Copyright © 1985 by American College of Chest Physicians

ARTICLES

Regional myocardial blood flow in man during dipyridamole coronary vasodilation

SG Sorensen, BM Groves, LD Horwitz and TK Chaudhuri

Regional myocardial blood flow before and after intravenous dipyridamole (0.56 mg/kg) was measured during cardiac catheterization in 11 patients using the 133Xe washout technique. Significant increases in heart rate (75 +/- 4 vs 87 +/- 6, p less than 0.004) and decreases in systolic blood pressure (144 +/- 8 vs 131 +/- 7, p less than 0.02) were observed with dipyridamole infusion. However, double product and cardiac output did not differ before or after drug infusion. Regional myocardial blood flow increased from 67 +/- 3 (SEM) to 117 +/- 3 ml/100 mg/min in myocardial segments supplied by nonobstructed coronary arteries. In stenotic coronary arteries, flow increased from 57 +/- 5 to 79 +/- 9 ml/100 mg/min with dipyridamole. We conclude that dipyridamole infusion results in flow differences which discriminate stenotic from nonstenotic coronary arteries.


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E.L.L.M. De Schryver
Dipyridamole in Stroke Prevention: Effect of Dipyridamole on Blood Pressure
Stroke, October 1, 2003; 34(10): 2339 - 2342.
[Abstract] [Full Text] [PDF]


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Copyright © 1985 by the American College of Chest Physicians.