Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cotromanes, E.
Right arrow Articles by Lourenco, R. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cotromanes, E.
Right arrow Articles by Lourenco, R. V.

Chest, Vol 88, 194-200, Copyright © 1985 by American College of Chest Physicians

ARTICLES

Aerosol penetration and mucociliary transport in the healthy human lung. Effect of low serum theophylline levels

E Cotromanes, TR Gerrity, CS Garrard, RD Harshbarger, DB Yeates, DL Kendzierski and RV Lourenco

The effect of theophylline on the penetration of an inhaled radioaerosol in the lung, bronchial clearance, and tracheal mucociliary transport rate (TMTR) was investigated in 13 healthy volunteers. Following a randomized, double-blind, crossover protocol, subjects ingested 4 mg/kg twice daily of theophylline or placebo for three days which resulted in stable, low therapeutic serum levels. Aerosol penetration, assessed by the skew of the initial distribution of lung radioactivity, was more peripheral (p less than 0.025) with theophylline, indicating bronchodilation that was not detectable by standard pulmonary function tests. The TMTR increased in ten of 13 subjects after theophylline, but not to a significant level. Bronchial clearance was not significantly different with theophylline despite the longer clearance pathway created by the increased peripheral aerosol deposition. This finding suggests that mucus transport rates in the intrapulmonary airways were increased by theophylline.


This article has been cited by other articles:


Home page
 ChestHome page
R. S. Ream, L. L. Loftis, G. M. Albers, B. A. Becker, R. E. Lynch, and R. B. Mink
Efficacy of IV Theophylline in Children With Severe Status Asthmaticus
Chest, May 1, 2001; 119(5): 1480 - 1488.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. Weinberger and L. Hendeles
Theophylline in Asthma
N. Engl. J. Med., May 23, 1996; 334(21): 1380 - 1388.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the American College of Chest Physicians.