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Chest, Vol 88, 210S-213S, Copyright © 1985 by American College of Chest Physicians

ARTICLES

Interactions of endothelial cells and smooth muscle cells of arteries

RF Furchgott and W Martin

Relaxation of selected isolated arteries by acetylcholine, bradykinin, and certain other vasodilators is mediated by a factor released from endothelial cells. Relaxation by the factor (chemical identity still unknown) is accompanied by an increase of cyclic GMP. The finding that hemoglobin inhibits both endothelium-dependent relaxation and the increase in cyclic GMP may have pathophysiologic relevance.


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Copyright © 1985 by the American College of Chest Physicians.