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(Chest. 1985;88:207S-209S.)
© 1985 American College of Chest Physicians

Peptides, Endothelium, and Pulmonary Vascular Reactivity

Sami I. Said M.D.1

1 From the University of Oklahoma, Health Sciences Center, and VA Medical Center, Oklahoma City

The lung contains a number of active peptides that can influence endothelial and smooth muscle function. At least two of these peptides are metabolized by endothelium, and endothelium is required for the vasodilator action of several peptides. A vasodilator peptide, VIP, may be the transmitter of the nonadrenergic, noncholinergic system, the major component of neurogenic relaxation of pulmonary vessels.






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Copyright © 1985 by the American College of Chest Physicians.