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(Chest. 1985;88:210S-213S.)
© 1985 American College of Chest Physicians

Interactions of Endothelial Cells and Smooth Muscle Cells of Arteries

Robert F. Furchgott Ph.D.1 and William Martin Ph.D.1

1 From the Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn

Relaxation of selected isolated arteries by acetylcholine, bradykinin, and certain other vasodilators is mediated by a factor released from endothelial cells. Relaxation by the factor (chemical identity still unknown) is accompanied by an increase of cyclic GMP. The finding that hemoglobin inhibits both endothelium-dependent relaxation and the increase in cyclic GMP may have pathophysiologic relevance.






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Copyright © 1985 by the American College of Chest Physicians.