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(Chest. 1985;88:213S-216S.)
© 1985 American College of Chest Physicians

Effects of Endothelial Cell Injury on Pulmonary Vascular Reactivity

Sharon Rounds M.D.1; Harrison W. Farber M.D.1; Nicholas S. Hill M.D., F.C.C.P.1; and Richard F. O'Brien M.D.1

1 From the Pulmonary Center, Evans Memorial Department of Clinical Research and Medicine, Boston University School of Medicine, Boston

Using the thiocarbamide model of acute lung injury in rats, we found that agr-naphthylthiourea (ANTU) caused lung endothelial cell injury, as evidenced by increased permeability edema and decreased angiotensin I conversion. These effects were associated with enhanced pulmonary vascular reactivity. Recurrent ANTU lung injury caused pulmonary hypertension. The water-soluble thiocarbamide thiourea caused cultured vascular endothelial cells to release neutrophil chemoattractant activity. We speculate that endothelial cell injury may modulate the function of vascular smooth muscle and blood leukocytes.






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Copyright © 1985 by the American College of Chest Physicians.