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(Chest. 1985;88:229S-232S.)
© 1985 American College of Chest Physicians

Effect of Oxygen Concentration on Cellular Metabolism

David F. Wilson Ph.D.1 and Maria Erecinacuteska M.D.1

1 From the Departments of Biochemistry and Biophysics and of Pharmacology, Medical School, University of Pennsylvania, Philadelphia

Experimental evidence is presented that mitochondrial oxidative phosphorylation is dependent on oxygen concentration in its physiologic range both in vivo and in vitro. Mitochondrial oxidative phosphorylation is considered to act as a tissue oxygen sensor important for controlling local vascular resistance.






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Copyright © 1985 by the American College of Chest Physicians.