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(Chest. 1985;88:245S-248S.)
© 1985 American College of Chest Physicians

Potential Role of Arachidonic Acid Metabolites in Hypoxic Pulmonary Vasoconstriction

N. F. Voelkel M.D.1; M. Morganroth M.D.1; and O. C. Feddersen M.D.1

1 From the Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver

Hypoxic vasoconstriction is important for lung ventilation/perfusion matching. The mechanism of hypoxic vasoconstriction remains elusive. Arachidonic acid is released from hypoxic tissues; possibly vasoconstricting arachidonate metabolites are involved in hypoxic pulmonary vasoconstriction. Data are presented that consider (a) lipoxygenase product(s) as "local," which could be involved in the hypoxia induced pulmonary vasoconstriction.







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Copyright © 1985 by the American College of Chest Physicians.