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(Chest. 1985;88:255S-257S.)
© 1985 American College of Chest Physicians

Pulmonary Gas Exchange and Exercise Performance in Pulmonary Hypertension

David R. Dantzker M.D., F.C.C.P.1 and Gilbert E. D'Alonzo D.O.1

1 From Pulmonary Division, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston

Patients with pulmonary hypertension have disordered pulmonary gas exchange and impaired exercise tolerance. The hypoxemia is due to mild ventilation-perfusion (VA/Q) inequality exaggerated by the presence of a low mixed venous Po2 (PvO2) and is accentuated during exercise due to a further fall in PvO2. This in turn may be worsened by vasodilators which increase the degree of VA/Q inequality. Decreased exercise tolerance is due predominantly to cardiac limitation, and thus an improvement in cardiac function subsequent to successful vasodilitation can be assessed by improved exercise performance.






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Copyright © 1985 by the American College of Chest Physicians.