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(Chest. 1985;88:260S-263S.)
© 1985 American College of Chest Physicians

Use of Calcium Channel Blockers in Hypoxic Lung Disease

John R. Michael M.D., F.C.C.P.1; Stephen Selinger M.D.1; William Parham M.D.1; Phillip Buescher M.D.1; Dean Wong M.D.1; and Thomas P. Kennedy M.D., M.P.H., F.C.C.P.1

1 From the Departments of Medicine, Anesthesiology and Critical Care Medicine, and Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore

COPD patients who are hypoxic develop pulmonary hypertension primarily because alveolar hypoxia induces muscular hypertrophy of pulmonary arteries. This muscular hypertrophy will regress in animals if they receive continuous oxygen therapy. Since many COPD patients refuse to use oxygen continuously, calcium channel blockers, which inhibit hypoxic pulmonary vasoconstriction, may be effective adjuvant therapy. Nifedipine lowers pulmonary vascular resistance during rest and exercise in hypoxic COPD patients.






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Copyright © 1985 by the American College of Chest Physicians.