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(Chest. 1985;88:265S-268S.)
© 1985 American College of Chest Physicians

Does Pulmonary Vasoconstriction Play an Important Role in Patients with Primary Pulmonary Hypertension?

A Skeptic's View of Vasodilator Therapy

Milton Packer M.D.1

1 From the Division of Cardiology, Department of Medicine, Mount Sinai School of Medicine of The City University of New York

Despite isolated reports of dramatic hemodynamic and clinical improvement over the past 30 years, most patients with primary pulmonary hypertension fail to benefit from treatment with vasodilator drugs and many develop serious adverse reactions. The failure of this approach strongly suggests that pulmonary vasoconstriction does not play an important role in the pathogenesis of this disorder.






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Copyright © 1985 by the American College of Chest Physicians.