Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eliasson, O
Right arrow Articles by McCormick, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Eliasson, O
Right arrow Articles by McCormick, J.

Chest, Vol 89, 484-490, Copyright © 1986 by American College of Chest Physicians

ARTICLES

Corticosteroids in COPD. A clinical trial and reassessment of the literature

O Eliasson, J Hoffman, D Trueb, D Frederick and JR McCormick

A placebo-controlled, double-blind cross-over trial was conducted to assess whether 16 men with chronic obstructive pulmonary disease (COPD) would benefit from orally taken corticosteroids. Two weeks of treatment with 40 mg of prednisone daily did not result in improvement of pulmonary symptoms or function in the group as a whole, although one patient had small improvement in airflow. The baseline spirometric data and beta-agonist responsiveness of the patients in the study were then compared to a reference population consisting of 264 men who fulfilled a criteria for chronic obstruction out of 730 men who comprised a systematic sample drawn from all patients referred for spirometry at three hospitals. Our study subjects and those of five similar trials of corticosteroids in COPD had more severe obstruction than this reference group. Furthermore, the proportion of steroid responders found in each study was inversely related to the baseline FEV1 of the patients examined. It appears that previous studies of corticosteroids in COPD may have overestimated the number of COPD patients who might benefit from corticosteroids, due to a bias resulting from the selection of severely obstructed subjects.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
K. L. RICE, J. B. RUBINS, F. LEBAHN, C. M. PARENTI, P. G. DUANE, M. KUSKOWSKI, A. M. JOSEPH, and D. E. NIEWOEHNER
Withdrawal of Chronic Systemic Corticosteroids in Patients with COPD . A Randomized Trial
Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 174 - 178.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. E. NIEWOEHNER, D. COLLINS, and M. L.E. f. t. D. o.  Veterans Affairs Cooperative Study
Relation of FEV1 to Clinical Outcomes during Exacerbations of Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1201 - 1205.
[Abstract] [Full Text]

Home page
 NEJMHome page
R. A. Pauwels, C.-G. Lofdahl, L. A. Laitinen, J. P. Schouten, D. S. Postma, N. B. Pride, S. V. Ohlsson, and The European Respiratory Society Study on Chronic
Long-Term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking
N. Engl. J. Med., June 24, 1999; 340(25): 1948 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. PIZZICHINI, M. M. M. PIZZICHINI, P. GIBSON, K. PARAMESWARAN, G. J. GLEICH, L. BERMAN, J. DOLOVICH, and F. E. HARGREAVE
Sputum Eosinophilia Predicts Benefit from Prednisone in Smokers with Chronic Obstructive Bronchitis
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(5): 1511 - 1517.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American College of Chest Physicians.