Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Horne, S.
Right arrow Articles by Dosman, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Horne, S.
Right arrow Articles by Dosman, J.

Chest, Vol 89, 795-799, Copyright © 1986 by American College of Chest Physicians

ARTICLES

Pulmonary function in Pi M and MZ grainworkers

SL Horne, RK Tennent, DW Cockcroft, DJ Cotton and JA Dosman

Twenty-eight men with the Pi MZ phenotype who have been employed in the Saskatchewan country grain elevators and thus regularly exposed to high levels of grain dust, were case matched for age, years of employment, employment status, smoking status, and smoking history with grainworkers of type Pi M. Individuals answered a questionnaire, had a chest roentgenogram, skin tests, and performed a battery of pulmonary function tests. There were no differences between the two groups in prevalence of symptoms or atopy. Although not statistically significant, the MZ group had three times as many individuals with abnormal roentgenograms suggestive of COPD as the M group. The Pi MZ grainworkers had consistently poorer mean results for the pulmonary function tests with significantly lower mean values for FEV1, FEV1/FVC, MMFR, and Vmax50, leading us to suggest that Pi MZ individuals may be at higher risk of COPD than Pi M individuals, but only in the presence of other risk factors such as grain dust exposure.


This article has been cited by other articles:


Home page
 Eur Respir JHome page
O. Senn, E. W. Russi, M. Imboden, and N. M. Probst-Hensch
{alpha}1-Antitrypsin deficiency and lung disease: risk modification by occupational and environmental inhalants
Eur. Respir. J., November 1, 2005; 26(5): 909 - 917.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Dahl, C. P. Hersh, N. P. Ly, C. S. Berkey, E. K. Silverman, and B. G. Nordestgaard
The protease inhibitor PI*S allele and COPD: a meta-analysis
Eur. Respir. J., July 1, 2005; 26(1): 67 - 76.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
C P Hersh, M Dahl, N P Ly, C S Berkey, B G Nordestgaard, and E K Silverman
Chronic obstructive pulmonary disease in {alpha}1-antitrypsin PI MZ heterozygotes: a meta-analysis
Thorax, October 1, 2004; 59(10): 843 - 849.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
American Thoracic Society/European Respiratory Society Statement: Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 818 - 900.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. S. MAYER, J. K. STOLLER, B. B. BARTELSON, A. JAMES RUTTENBER, R. A. SANDHAUS, and L. S. NEWMAN
Occupational Exposure Risks in Individuals with PI*Z alpha 1-Antitrypsin Deficiency
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 553 - 558.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American College of Chest Physicians.