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Chest, Vol 90, 454-455, Copyright © 1986 by American College of Chest Physicians

ARTICLES

Embolic stroke in a woman with mitral valve prolapse who used oral contraceptives

EH Busch, DW Snyder and RE Barron 3d

A case of angiographically-documented embolism is presented in a patient using oral contraceptives (OC) with marked mitral valve prolapse (MVP) and an atrial thrombus. OC use has been shown to decrease levels of antithrombin III and increase platelet coagulant activity. This increased coagulability may increase the risk of intra- atrial thrombus formation and subsequent cerebral embolism in patients with MVP. We believe that MVP, especially when redundant valve leaflets are recognized, may be a relative contraindication to OC use.


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D. Gilon, F. S. Buonanno, M. M. Joffe, M. Leavitt, J. E. Marshall, J. P. Kistler, and R. A. Levine
Lack of Evidence of an Association between Mitral-Valve Prolapse and Stroke in Young Patients
N. Engl. J. Med., July 1, 1999; 341(1): 8 - 13.
[Abstract] [Full Text] [PDF]


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Copyright © 1986 by the American College of Chest Physicians.