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Chest, Vol 91, 338-341, Copyright © 1987 by American College of Chest Physicians

ARTICLES

Lymphocyte subpopulations, activation phenotypes, and spontaneous proliferation in tuberculous pleural effusions

V Bergroth, YT Konttinen, D Nordstrom, T Pettersson and E Tolvanen

The state of lymphocyte activation in tuberculous pleural effusions was studied. The proportion of cells at and beyond the G1 phase of the cell cycle displaying interleukin-2 receptor, transferrin receptor or gp 40/80 glycoprotein in avidin-biotin-peroxidase complex (ABC) staining was 6 +/- 2 percent, 8 +/- 3 percent, and 14 +/- 4 percent of all pleural fluid mononuclear cells, respectively. These findings imply that only a fraction of pleural fluid lymphocytes is activated in tuberculosis. The proportion of autoradiographically visualized 3H- thymidine incorporating blasts at the S phase of the cell cycle was 1.2 +/- 0.3 percent. This phenomenon further confirms the impression that, in spite of activation, most of the pleural fluid mononuclear cells are resting cells. The T4/T8 ratio in the functionally active blast cell population determined by a double labeling method combining ABC staining with autoradiography was similar to the total T4/T8 ratio (2.3 +/- 0.7 vs 2.7 +/- 0.8, p greater than 0.05) calculated for all pleural fluid mononuclear cells.


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 Am. J. Respir. Crit. Care Med.Home page
E. PACE, M. GJOMARKAJ, M. MELIS, M. PROFITA, M. SPATAFORA, A. M. VIGNOLA, G. BONSIGNORE, and C. H. MODY
Interleukin-8 Induces Lymphocyte Chemotaxis into the Pleural Space . Role of Pleural Macrophages
Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1592 - 1599.
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Copyright © 1987 by the American College of Chest Physicians.