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Chest, Vol 91, 688-692, Copyright © 1987 by American College of Chest Physicians

ARTICLES

Effect of chlormadinone acetate on sleep arterial oxygen desaturation in patients with chronic obstructive pulmonary disease

K Tatsumi, H Kimura, F Kunitomo, T Kuriyama, S Watanabe and Y Honda

Twelve patients with chronic obstructive pulmonary disease (COPD) were studied in order to evaluate the effect of chlormadinone acetate (CMA), a potent synthetic progesterone, on the degree of hypoxemia during sleep. In patients designated as "correctors," in whom an increase in minute ventilation (VI) during wakefulness was brought about mainly by an increase in tidal volume (VT) and PaCO2 was effectively decreased by the administration of CMA, this agent also proved to be effective during sleep, with hypoxemia improved during both NREM and REM sleep. On the other hand, in patients called "noncorrectors" in whom a decrease in PaCO2 was not seen during wakefulness with CMA, there was also no effect during sleep. These results indicate that CMA is effective in certain selected patients with COPD.


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J. Weisberg, J. Wanger, J. Olson, B. Streit, C. Fogarty, T. Martin, and R. Casaburi
Megestrol Acetate Stimulates Weight Gain and Ventilation in Underweight COPD Patients*
Chest, April 1, 2002; 121(4): 1070 - 1078.
[Abstract] [Full Text] [PDF]


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Copyright © 1987 by the American College of Chest Physicians.