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Chest, Vol 92, 124-128, Copyright © 1987 by American College of Chest Physicians

ARTICLES

Prehospital coronary thrombolysis. A new strategy in acute myocardial infarction

AT Weiss, DG Fine, D Applebaum, S Welber, D Sapoznikov, C Lotan, M Mosseri, Y Hasin and MS Gotsman

Thirty-four patients with acute myocardial infarction were treated prospectively using a new strategy of prehospital intravenous streptokinase given by a physician-operated mobile intensive care unit. The 29 prehospital-treated patients who had experienced no previous myocardial infarction were compared to a similar group treated with streptokinase inhospital. Patients receiving streptokinase in the prehospital phase of acute myocardial infarction had smaller infarcts and better residual myocardial function than the group given streptokinase inhospital in terms of peak creatinine phosphokinase, ejection fraction, computer-derived dysfunction index, and electrocardiographic QRS score. The only difference between these groups at baseline was the duration of pain prior to initiation of streptokinase therapy. There were no major complications related to prehospital administration of streptokinase.


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M S V M Chittari, I Ahmad, B Chambers, F Knight, A Scriven, and D Pitcher
Retrospective observational case-control study comparing prehospital thrombolytic therapy for ST-elevation myocardial infarction with in-hospital thrombolytic therapy for patients from same area
Emerg. Med. J., August 1, 2005; 22(8): 582 - 585.
[Abstract] [Full Text] [PDF]

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 NEJMHome page
The European Myocardial Infarction Project Group
Prehospital Thrombolytic Therapy in Patients with Suspected Acute Myocardial Infarction
N. Engl. J. Med., August 5, 1993; 329(6): 383 - 389.
[Abstract] [Full Text]


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