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Chest, Vol 92, 129-131, Copyright © 1987 by American College of Chest Physicians

ARTICLES

Evaluation of whole blood theophylline enzyme immunochromatography assay

MP Habib, RB Schifman, BY Shon, JF Fiastro and SC Campbell

A new whole blood enzyme immunochromatographic (EIC) theophylline assay was evaluated in 18 low (25 to 37 percent) and 15 high hematocrit (49 to 56 percent) samples. A good correlation was observed between EIC and fluorescence polarization methods for plasma samples (r = 0.95). However, comparison of results between EIC whole blood and plasma values demonstrates a significant proportional bias that is inversely related to the sample's hematocrit. The EIC method for whole blood samples may substantially underestimate theophylline levels in polycythemic patients with theophylline values near or above the toxic range and underestimate levels in those with anemia, if a correction is not made for the sample's hematocrit. A correction formula to approximate plasma theophylline concentrations from whole blood measurements is described.


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H.-s. Shin, C.-k. Kim, K.-s. Shin, H.-k. Chung, and T.-r. Heo
Pretreatment of Whole Blood for Use in Immunochromatographic Assays for Hepatitis B Virus Surface Antigen
Clin. Vaccine Immunol., January 1, 2001; 8(1): 9 - 13.
[Abstract] [Full Text] [PDF]


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Copyright © 1987 by the American College of Chest Physicians.