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Chest, Vol 92, 15S-21S, Copyright © 1987 by American College of Chest Physicians

REVIEWS

The effect of theophylline and beta 2 agonists on airway reactivity

RC Ahrens, G Milavetz and J Joad

Increased airway responsiveness occurs in asthma, chronic bronchitis, cystic fibrosis, and other diseases. Theophylline and beta 2 agonists commonly are used as maintenance therapy for symptoms associated with the increased responsiveness. Both drugs can reduce airway responsiveness to a variety of provocational stimuli. With currently used dosing regimens, theophylline appears to produce relatively constant levels of effect on airway responsiveness and clinical efficacy around the clock, while inhaled beta 2 agonists appear to have insufficient effects at the end of longer dosing intervals. Improved dosing strategies for beta 2 agonists may improve the efficacy of these agents in the future.




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Copyright © 1987 by the American College of Chest Physicians.