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(Chest. 1987;92:22S-26S.)
© 1987 American College of Chest Physicians

Favorable Cardiovascular Effects of Theophylline in COPD

Richard A. Matthay M.D., F.C.C.P.1

1 Professor of Medicine and Associate Director, Pulmonary Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

In addition to its favorable bronchodilatory effects in patients with COPD, theophylline administered orally or intravenously clearly enhances cardiovascular performance. Both right and left ventricular systolic pump function are acutely, subacutely, and chronically improved by this agent. The mechanisms for these favorable actions appear to be twofold, namely; positive inotropic effects of theophylline and reduction in ventricular afterload. Physicians should consider these additional positive effects in patients with COPD when contemplating the administration of theophylline.






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Copyright © 1987 by the American College of Chest Physicians.