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Chest, Vol 92, 1088-1093, Copyright © 1987 by American College of Chest Physicians

ARTICLES

Effects of ibuprofen on the hypoxemia of established ethchlorvynol- induced unilateral acute lung injury in anesthetized dogs

RS Sprague, AH Stephenson, TE Dahms, NG Asner and AJ Lonigro
Medical Service, Veterans Administration Medical Center, St. Louis.

Nonsteroidal anti-inflammatory agents, given prior to induction of unilateral acute lung injury with ethchlorvynol (ECV) in anesthetized dogs, prevent the decreases in systemic oxygen tension (PaO2) which are observed when ECV is given alone. We investigated whether ibuprofen, administered after acute lung injury, would result in improvement in arterial oxygenation. In animals not receiving ibuprofen after unilateral acute lung injury with ECV, PaO2 decreased and venous admixture increased significantly from control values at all experimental time-periods. In those animals receiving ibuprofen, significant decreases in venous admixture were noted. The decrease in PaO2 after ECV administration was significantly less than that observed in animals that did not receive ibuprofen after acute lung injury (p less than 0.05). Ibuprofen had no effect on extravascular lung water. These results demonstrate that in an ECV model of acute lung injury the administration of ibuprofen, after the acute lung injury, results in significant decreases in venous admixture.


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