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(Chest. 1988;93:110-113.)
© 1988 American College of Chest Physicians

Plasma Cells in the Bronchoalveolar Lavage Fluid of a Patient with Eosinophilic Pneumonia

Morphologic Proof of Local Production of Antibodies

Etsuro Yamaguchi M.D.1; Shunpei Saito M.D.1; Nozomu Okazaki M.D.1; Shosaku Abe M.D.1; and Yoshikazu Kawakami M.D., F.C.C.P.1

1 From the First Department of Internal Medicine, School of Medicine, Hokkaido University, Sapporo, Japan

We describe a case of eosinophilic pneumonia in which plasma cells appeared in bronchoalveolar lavage fluid (BALF). A 49-year-old man presented with wheezing, lung infiltrates, peripheral eosinophilia, and extremely high IgE levels in serum and BALF. A differential count of BALF revealed 56.6 percent lymphocytes and 1.3 percent plasma cells. The appearance of plasma cells suggests local maturation of B cells and represents a morphologic proof of local production of immunoglobulins. The increased number of lymphocytes suggests their role in B cell differentiation via the lymphokine network.

Submitted on March 23, 2007
Accepted on June 11, 2007







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