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(Chest. 1988;93:26-30.)
© 1988 American College of Chest Physicians

Distribution of Bronchial Nonspecific Reactivity in the General Population

Isa Cerveri M.D.1; Claudio Bruschi M.D.1; Maria C. Zoia M.D.1; Pietro Zanon M.D.1; Laura Maccarini M.Sc.2; Mario Grassi M.Sc.3; and Ciro Rampulla M.D.4

1 Istituto di Tisiologia e Mal App Resp, Universitá di Pavia, Pavia, Italy
2 Centro di Ecologia Umana, Universitá di Pavia, Italy
3 Istituto de Scienze Sanitarie Applicate, Universitá di Pavia
4 Centro Medico Montescano, Fondazione Clinica del Lavoro, Pavia

We investigated 654 subjects of a small Lombardy (Italy) town between 15 and 64 years of age who were representative of the general population. By clinical examination, the sample included 535 normal subjects (164 normal smokers, 341 normal nonsmokers, 30 normal subjects with acute upper respiratory illness within 30 days before the challenge), 50 with chronic bronchitis, 26 with asthma, and 43 with allergic rhinitis. Subjects whose FEV1 was 75 percent or more than the predicted value (654) underwent methacholine bronchial challenge by means of 1 percent metered-dose solution. The test result was considered positive at a drop of more than 15 percent in FEV1 (compared with buffer). Normal smokers and all of the groups with disease had a significantly different distribution of reactivity compared with normal nonsmokers. The difference between asthmatic and these "normal" subjects was highly significant; nevertheless, a clear cut-off between the two groups does not appear to exist.

Submitted on January 30, 2007
Accepted on April 21, 2007




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