Chest Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stokes, D.
Right arrow Articles by Murphy, E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Stokes, D.
Right arrow Articles by Murphy, E.

Chest, Vol 93, 364-369, Copyright © 1988 by American College of Chest Physicians

ARTICLES

Spirometry and chest wall dimensions in achondroplasia

DC Stokes, RE Pyeritz, RA Wise, D Fairclough and EA Murphy
Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD.

Standard values for pulmonary function in short-limbed dwarfism are not available. Therefore, chest diameters and expiratory spirograms were measured in 58 female and 44 male subjects between 7 and 60 years of age with achondroplasia, the most common form of dwarfism. Standing height in adults was 49.6 +/- 3.2 (SD) inches with a sitting/standing height ratio of 0.66 (normal 0.52-0.53). Despite extremely short stature, only AP chest diameters in males were smaller than control subjects of similar age. The following equations were derived for forced vital capacity (FVC): males (under 25 years), FVC(L) = -3.56 + 0.162 X sitting height (in) + 0.067 X age (yrs); males (over 25 years), FVC(L) = -0.73 + 0.162 X sitting height (in) -0.047 X age (yrs); females (under 20 years), FVC(L) = -3.56 + 0.150 X sitting height (in) + 0.067 X age (yrs); females (over 20 years), FVC(L) = -1.92 + 0.150 X sitting height (in) -0.016 X age (years). Similar prediction equations were derived for FEV1 and FEF25-75%: FEV1/FVC % was 84.2 (+/- 6.5) for females and 88.0 (+/- 6.5) for males. We also compared the observed FVC measurements to values calculated using standing heights derived from the subject's sitting height, assuming a normal body proportion. The observed vital capacity in achondroplasia was only 67.6 (+/- 19.2) percent of that predicted for normally proportioned females and 72.4 (+/- 13.6) percent for males, suggesting reduced vital capacity in achondroplasia, due to reduced chest wall compliance or abnormal lung growth.


This article has been cited by other articles:


Home page
 Arch Otolaryngol Head Neck SurgHome page
W. O. Collins and S. S. Choi
Otolaryngologic Manifestations of Achondroplasia
Arch Otolaryngol Head Neck Surg, March 1, 2007; 133(3): 237 - 244.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
P. Harmatz, D. Ketteridge, R. Giugliani, N. Guffon, E. L. Teles, M. C. S. Miranda, Z.-F. Yu, S. J. Swiedler, J. J. Hopwood, and for the MPS VI Study Group
Direct Comparison of Measures of Endurance, Mobility, and Joint Function During Enzyme-Replacement Therapy of Mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome): Results After 48 Weeks in a Phase 2 Open-Label Clinical Study of Recombinant Human N-Acetylgalactosamine 4-Sulfatase
Pediatrics, June 1, 2005; 115(6): e681 - e689.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
R. C Tasker, I. Dundas, A. Laverty, M. Fletcher, R. Lane, and J. Stocks
Distinct patterns of respiratory difficulty in young children with achondroplasia: a clinical, sleep, and lung function study
Arch. Dis. Child., August 1, 1998; 79(2): 99 - 108.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by the American College of Chest Physicians.