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Chest, Vol 94, 1303-1306, Copyright © 1988 by American College of Chest Physicians

ARTICLES

Recurrent ventricular tachycardia due to pentamidine-induced cardiotoxicity

MR Bibler, TC Chou, RJ Toltzis and PA Wade
Department of Internal Medicine, University of Cincinnati College of Medicine 45267-0535.

Although pentamidine isethionate is effective in the treatment of Pneumocystis carinii pneumonia, it frequently causes serious adverse reactions. We report a case of reversible pentamidine-induced cardiotoxicity, characterized electrocardiographically by prolongation of the QT interval, T-wave inversion, and electrical alternans of the U- wave. In addition, the patient had repeated episodes of ventricular tachycardia that culminated in torsades de pointes. Our case re- emphasizes the need for close patient monitoring during pentamidine therapy.


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[Abstract] [Full Text] [PDF]


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Copyright © 1988 by the American College of Chest Physicians.