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Chest, Vol 95, 136-138, Copyright © 1989 by American College of Chest Physicians

ARTICLES

Diagnosis of Pneumocystis carinii pneumonia by induced sputum in a city with moderate incidence of AIDS

RF O'Brien, JL Quinn, BT Miyahara, RB Lepoff and DL Cohn
Department of Medicine, (Pulmonary and Infectious Disease Divisions), Denver General Hospital, University of Colorado Health Sciences Center.

Examination of induced sputum from AIDS patients has been reported to provide the noninvasive diagnosis of PCP in 10 to 76 percent of cases. Since previous studies were done in centers with a high incidence of AIDS, we asked whether this test could be implemented successfully in a center with a lower incidence of AIDS. Over a 13-month period 25 of 38 (66 percent) AIDS patients with PCP had positive Giemsa (Diff-Quik) stains of induced sputum. We were unable to predict before sputum induction which patients would be positive based on clinical severity (increased A-a gradient or serum LDH levels). We confirmed prior observations that a normal serum LDH level was found in only 5 percent of documented PCP cases. This noninvasive technique significantly decreased the number of bronchoscopies performed and led to a considerable cost savings.


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Nonspecific Interstitial Pneumonitis Mimicking Pneumocystis carinii Pneumonia
Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 912 - 917.
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