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Chest, Vol 95, 596-597, Copyright © 1989 by American College of Chest Physicians

ARTICLES

Pleural T-lymphocyte subsets in amiodarone-associated pleuropneumonitis

GM Akoun, BJ Milleron, DM Badaro, CM Mayaud and HA Liote
Chest Disease Department, Hopital Tenon, Paris, France.

Two male patients presented with lung disorders with all the characteristics of amiodarone-related pneumonitis. Bilateral exudative pleural effusions were associated with pneumonitis. High lymphocytosis was present in the pleural fluid with a ratio of T-lymphocyte subsets close to that found in peripheral blood; in the blood T-lymphocyte subset ratio was nearly normal. By contrast, and as is usual in similar cases, lymphocytic alveolitis with T-lymphocyte subset imbalance was found in bronchoalveolar lavage fluid. These findings, never published so far to our knowledge, would favor a compartmentalization of the immune response inside the lung.




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Copyright © 1989 by the American College of Chest Physicians.