Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laube, B.
Right arrow Articles by Rosenstein, B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Laube, B.
Right arrow Articles by Rosenstein, B.

Chest, Vol 95, 822-830, Copyright © 1989 by American College of Chest Physicians

ARTICLES

Homogeneity of bronchopulmonary distribution of 99mTc aerosol in normal subjects and in cystic fibrosis patients

BL Laube, JM Links, ND LaFrance, HN Wagner Jr and BJ Rosenstein
Department of Medicine, Johns Hopkins University Medical Institutions, Baltimore.

We characterized the bronchopulmonary distribution of a 0.9 percent saline aerosol (1.12 microM) labelled with 99mTc sulfur colloid in nine normal subjects and five patients with CF. Homogeneity of distribution was quantified using indices derived from computerized analysis of Anger camera pulmonary images including skew (a measure of distribution asymmetry) and kurtosis (a measure of distribution range). Aerosol clearance in 97 minutes (a measure of large, central airway deposition) was also assessed. Values of skew and kurtosis were reproducible for the patients with CF and were significantly elevated compared to the normal subjects. Reproducibility of skew and kurtosis were not studied in the normal subjects. Clearance was not significantly different in the two groups. We conclude that the bronchopulmonary distribution of this radioaerosol is nonuniform in patients with CF, compared to normal subjects, and clearance may be impaired in patients with CF who are severely ill.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
B. FAUROUX, E. ITTI, J. PIGEOT, D. ISABEY, M. MEIGNAN, G. FERRY, F. LOFASO, J.-M. WILLEMOT, A. CLÉMENT, and A. HARF
Optimization of Aerosol Deposition by Pressure Support in Children with Cystic Fibrosis . An Experimental and Clinical Study
Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2265 - 2271.
[Abstract] [Full Text]

Home page
 ChestHome page
B. L. Laube, R. Jashnani, R. N. Dalby, and P. L. Zeitlin
Targeting Aerosol Deposition in Patients With Cystic Fibrosis : Effects of Alterations in Particle Size and Inspiratory Flow Rate
Chest, October 1, 2000; 118(4): 1069 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Kapsali, S. Permutt, B. Laube, N. Scichilone, and A. Togias
Potent bronchoprotective effect of deep inspiration and its absence in asthma
J Appl Physiol, August 1, 2000; 89(2): 711 - 720.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
D. Wilson, M. Burniston, E. Moya, A. Parkin, S. Smye, P. Robinson, and J. Littlewood
Improvement of nebulised antibiotic delivery in cystic fibrosis
Arch. Dis. Child., April 1, 1999; 80(4): 348 - 352.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by the American College of Chest Physicians.