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Chest, Vol 96, 281-286, Copyright © 1989 by American College of Chest Physicians

ARTICLES

Bronchial responsiveness to exercise after human cardiopulmonary transplantation

AR Glanville, GM Gabb, J Theodore and ED Robin
Department of Medicine, Stanford University School of Medicine, CA.

Heart-lung transplant (HLT) recipients characteristically display marked bronchial hyperresponsiveness (BHR) to inhaled methacholine, but their bronchial responsiveness (BR) to exercise has not been reported. We measured BR to exercise in 13 stable HLT recipients, 13 normal control (NC) subjects and 13 asthmatic patients (AS). All subjects exercised for eight minutes on a bicycle ergometer at a work level designed to obtain and maintain 80 percent maximum heart rate, or to tolerance. The postexercise fall in FEV1 was equivalent in the HLT group and the NC group (0 +/- 0.2 L vs 0 +/- 0.2 L:p = NS) in contrast to the AS group (-0.6 +/- 0.5 L:p less than 0.01). Stable HLT recipients do not exhibit BHR to exercise at tolerable work loads. This observation supports the hypothesis that BHR to methacholine after HLT is due to denervation hypersensitivity of muscarinic receptors rather than other causes.


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S.M. Studer, R.D. Levy, K. McNeil, and J.B. Orens
Lung transplant outcomes: a review of survival, graft function, physiology, health-related quality of life and cost-effectiveness
Eur. Respir. J., October 1, 2004; 24(4): 674 - 685.
[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the American College of Chest Physicians.