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Chest, Vol 96, 505-508, Copyright © 1989 by American College of Chest Physicians

ARTICLES

Importance of evaporative water losses during standardized nebulized inhalation provocation tests

DW Cockcroft, TS Hurst and BP Gore
Department of Medicine, University of Saskatchewan, Saskatoon, Canada.

Evaporative water losses from jet nebulizers produce temperature drop, reduction in total nebulizer output with increased nebulization time, and increasing concentration of solute remaining in the nebulizer. These were documented and quantitated for the Wright nebulizer which is used for one histamine/methacholine inhalation test method. Indirect determination of nebulizer aerosol output, made by estimation of total sodium lost from the nebulizer, was about 25 percent of total output as determined by weight change. A similar tendency was seen for a De Vilbiss 40 nebulizer for both reduction in total nebulizer output with increasing duration of nebulization, and increased solute concentration remaining in the nebulizer. These data must be taken into account when standardizing inhalation provocation tests. Nebulizers should be calibrated under the same conditions that they are used during the test. Histamine and methacholine solutions should be discarded after a single use in the 2-min tidal breathing Wright nebulizer method.


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D. W. Cockcroft, B. E. Davis, and A. J. Smycniuk
Development of a Methacholine Challenge Method to Minimize Methacholine Waste
Chest, October 1, 2003; 124(4): 1522 - 1525.
[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the American College of Chest Physicians.