| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
Chest, Vol 96, 606-612, Copyright © 1989 by American College of Chest Physicians
ARTICLES |
JI Sznajder, A Fraiman, JB Hall, W Sanders, G Schmidt, G Crawford, A Nahum, P Factor and LD Wood
Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, Chicago 60616.
Acute hypoxemic respiratory failure (AHRF) can result from diverse lung insults. Toxic oxygen metabolites have been implicated in this clinical condition and in animal models of pulmonary edema. Hydrogen peroxide (H2O2), an oxygen metabolite, mediates tissue injury. We measured H2O2 levels by a spectrophotometric technique in the breath condensate of 68 mechanically ventilated patients; 13 patients with normal lungs undergoing elective surgery had no such detectable levels of H2O2. Fifty-five patients in the ICU meeting criteria for the adult respiratory distress syndrome (ARDS) had a higher concentration of H2O2 in the expired breath condensate than ICU patients without pulmonary infiltrates (2.34 +/- 1.15 vs 0.99 +/- 0.72 mumol/L, p less than 0.005). This marker had a sensitivity of 87.5 percent and a specificity of 81.3 percent in separating the two patient populations. Patients with AHRF and focal pulmonary infiltrates who did not meet criteria for ARDS also had higher concentrations of H2O2 (2.45 +/- 1.55 mumol/L) than patients without pulmonary infiltrates (p less than 0.001). No difference was observed between the expired H2O2 concentrations of patients with ARDS or patients with focal pulmonary infiltrates. Patients with brain injury or sepsis tended to have higher levels of H2O2 regardless of lung pathology. Increased levels of H2O2 are detected in the expired breath of ICU patients with focal lung infiltrates and in ARDS patients, which is consistent with the hypothesis that oxygen metabolites participate in the pathogenesis of ARDS and other forms of AHRF.
This article has been cited by other articles:
|
|
 |
|
  E. M. Mercken, G. J. Hageman, A. M. W. J. Schols, M. A. Akkermans, A. Bast, and E. F. M. Wouters Rehabilitation Decreases Exercise-induced Oxidative Stress in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., October 15, 2005; 172(8): 994 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Horvath, J. Hunt, P. J. Barnes, and On behalf of the ATS/ERS Task Force on Exhaled Bre Exhaled breath condensate: methodological recommendations and unresolved questions Eur. Respir. J., September 1, 2005; 26(3): 523 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Gessner, S. Hammerschmidt, H. Kuhn, T. Lange, L. Engelmann, J. Schauer, and H. Wirtz Exhaled Breath Condensate Nitrite and Its Relation to Tidal Volume in Acute Lung Injury Chest, September 1, 2003; 124(3): 1046 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vass, E. Huszar, E. Barat, M. Valyon, D. Kiss, I. Penzes, M. Augusztinovicz, and I. Horvath Comparison of Nasal and Oral Inhalation during Exhaled Breath Condensate Collection Am. J. Respir. Crit. Care Med., March 15, 2003; 167(6): 850 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Lang, P. J. McArdle, P. J. O'Reilly, and S. Matalon Oxidant-Antioxidant Balance in Acute Lung Injury Chest, December 1, 2002; 122(6_suppl): 314S - 320S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Hoidal Reactive Oxygen Species and Cell Signaling Am. J. Respir. Cell Mol. Biol., December 1, 2001; 25(6): 661 - 663. [Full Text] [PDF]
|
|
|
|
|
|
A. Emelyanov, G. Fedoseev, A. Abulimity, K. Rudinski, A. Fedoulov, A. Karabanov, and P. J. Barnes Elevated Concentrations of Exhaled Hydrogen Peroxide in Asthmatic Patients Chest, October 1, 2001; 120(4): 1136 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. MUTLU, K. W. GAREY, R. A. ROBBINS, L. H. DANZIGER, and I. RUBINSTEIN Collection and Analysis of Exhaled Breath Condensate in Humans Am. J. Respir. Crit. Care Med., September 1, 2001; 164(5): 731 - 737. [Full Text] [PDF]
|
|
|
|
|
|
I. Horvath, W. MacNee, F.J. Kelly, P.N.R. Dekhuijzen, M. Phillips, G. Doring, A.M.K. Choi, M. Yamaya, F.H. Bach, D. Willis, et al. "Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999 Eur. Respir. J., August 1, 2001; 18(2): 420 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Lases, V. A.M. Duurkens, W. B.M. Gerritsen, and F. J.L.M. Haas Oxidative Stress After Lung Resection Therapy: A Pilot Study Chest, April 1, 2000; 117(4): 999 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Hartwig, J. Werner, R. E. Jimenez, K. Z'graggen, J. Weimann, K. B. Lewandrowski, A. L. Warshaw, and C. F.-D. Castillo Trypsin and activation of circulating trypsinogen contribute to pancreatitis-associated lung injury Am J Physiol Gastrointest Liver Physiol, November 1, 1999; 277(5): G1008 - G1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Matute-Bello, W. C. Liles, K. P. Steinberg, P. A. Kiener, S. Mongovin, E. Y. Chi, M. Jonas, and T. R. Martin Soluble Fas Ligand Induces Epithelial Cell Apoptosis in Humans with Acute Lung Injury (ARDS) J. Immunol., August 15, 1999; 163(4): 2217 - 2225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. O. Heard, K. Longtine, I. Toth, J. C. Puyana, B. Potenza, and N. Smyrnios The Influence of Liposome-Encapsulated Prostaglandin E1 on Hydrogen Peroxide Concentrations in the Exhaled Breath of Patients with the Acute Respiratory Distress Syndrome Anesth. Analg., August 1, 1999; 89(2): 353 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Popovsky and S. L. Saidman Case 40-1998- A 49-Year-Old Woman with Thrombotic Thrombocytopenic Purpura and Severe Dyspnea during Plasmapheresis and Transfusion N. Engl. J. Med., December 31, 1998; 339(27): 2005 - 2012. [Full Text] [PDF]
|
|
|
|
|
|
I. HORVATH, L. E. DONNELLY, A. KISS, S. A. KHARITONOV, S. LIM, K. FAN CHUNG, and P. J. BARNES Combined Use of Exhaled Hydrogen Peroxide and Nitric Oxide in Monitoring Asthma Am. J. Respir. Crit. Care Med., October 1, 1998; 158(4): 1042 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Nathens, R. Bitar, R. W.G. Watson, T. B. Issekutz, J. C. Marshall, A. P.B. Dackiw, and O. D. Rotstein Thiol-Mediated Regulation of ICAM-1 Expression in Endotoxin-Induced Acute Lung Injury J. Immunol., March 15, 1998; 160(6): 2959 - 2966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Nathens, R. Bitar, C. Davreux, M. Bujard, J. C. Marshall, A. P. B. Dackiw, R. W. G. Watson, and O. D. Rotstein Pyrrolidine Dithiocarbamate Attenuates Endotoxin-induced Acute Lung Injury Am. J. Respir. Cell Mol. Biol., November 1, 1997; 17(5): 608 - 616. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. R. Michael, B. A. Markewitz, and D. E. Kohan Oxidant stress regulates basal endothelin-1 production by cultured rat pulmonary endothelial cells Am J Physiol Lung Cell Mol Physiol, October 1, 1997; 273(4): L768 - L774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. REPINE, A. BAST, I. LANKHORST, and The Oxidative Stress Study Gro Oxidative Stress in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., July 1, 1997; 156(2): 341 - 357. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
