Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murphy, D.
Right arrow Articles by Moore, R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Murphy, D.
Right arrow Articles by Moore, R.

Chest, Vol 96, 799-804, Copyright © 1989 by American College of Chest Physicians

ARTICLES

Local pulmonary ventilation using nonradioactive xenon-enhanced ultrafast computed tomography

DM Murphy, JT Nicewicz, SM Zabbatino and RA Moore
Deborah Heart and Lung Center, Department of Pulmonary Diseases, Browns Mills, NJ.

Using ultrafast computed tomography, we have developed a technique for measuring local ventilation in a volume of 1 cm3 in the normal supine lung. The technique employs the inert gas xenon in its nonradioactive form and makes use of its radiopaque properties. The inhalation of xenon results in changes in density which can be detected and measured in Hounsfield units using ultrafast computed tomography. Using this property and assuming a monoexponential form for the washin curve of the inert gas, it is possible to calculate ventilation at a local level. The methodology also permits measurements of minute ventilation during the procedure, thus permitting standardization. Using this technique, we calculated local ventilation in six normal subjects and have demonstrated a minor gradient in ventilation between the dorsal and ventral regions of the lung while in the supine position.


This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
E. A. Hoffman and D. Chon
Computed Tomography Studies of Lung Ventilation and Perfusion
Proceedings of the ATS, December 1, 2005; 2(6): 492 - 498.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. Yamaguchi, K. Soejima, E. Koda, and N. Sugiyama
Inhaling Gas With Different CT Densities Allows Detection of Abnormalities in the Lung Periphery of Patients With Smoking-Induced COPD
Chest, December 1, 2001; 120(6): 1907 - 1916.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. C. Kreck, M. A. Krueger, W. A. Altemeier, S. E. Sinclair, H. T. Robertson, E. D. Shade, J. Hildebrandt, W. J. E. Lamm, D. A. Frazer, N. L. Polissar, et al.
Determination of regional ventilation and perfusion in the lung using xenon and computed tomography
J Appl Physiol, October 1, 2001; 91(4): 1741 - 1749.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by the American College of Chest Physicians.