Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gorini, M
Right arrow Articles by Scano, G
Right arrow Search for Related Content
PubMed
Right arrow Articles by Gorini, M
Right arrow Articles by Scano, G

Chest, Vol 96, 824-830, Copyright © 1989 by American College of Chest Physicians

ARTICLES

Neural respiratory drive and neuromuscular coupling during CO2 rebreathing in patients with chronic interstitial lung disease

M Gorini, A Spinelli, R Ginanni, R Duranti, F Gigliotti, P Arcangeli and G Scano
Istituto di Clinica Medica III, Universita' degli Studi, Florence, Italy.

In 12 patients with CILD and 18 age-matched normal subjects we assessed the ventilatory control system at three levels: (a) neural, as assessed by EMGd (XP/Ti) and EMGint muscles via surface electrodes; (b) muscular, as assessed by mouth occlusion pressure (P0.1); and (c) ventilatory, as assessed by both ventilation (VE) and the related parameters, tidal volume (VT) and respiratory frequency (f). Compared with a normal control group, patients exhibited a significant decrease in lung volumes and in MIP; VT and inspiratory time (Ti) were significantly lower, while VT/Ti, P0.1, and both EMGd and EMGint were significantly greater in patients. During a CO2 rebreathing test, patients exhibited significantly greater EMGd, EMGint, and P0.1 responses to increasing PETCO2 than the control group. VE response slopes were similar in the two groups. For a given EMGd response slope (delta XP/Ti/delta PETCO2), the average P0.1 response slope (delta P0.1/delta PETCO2) was found to be significantly lower in patients than in the normal control group. Compared with normal subjects, CILD patients have a normal or increased neural component of respiratory activity and relatively low neuromuscular coupling (delta P0.1/delta XP/Ti). The decreased neuromuscular coupling could be explained in these patients by a reduced inspiratory muscle strength.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
F. Garcia-Rio, J. M. Pino, A. Ruiz, S. Diaz, C. Prados, and J. Villamor
Accuracy of noninvasive estimates of respiratory muscle effort during spontaneous breathing in restrictive diseases
J Appl Physiol, October 1, 2003; 95(4): 1542 - 1549.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. Misuri, B. Lanini, F. Gigliotti, I. Iandelli, A. Pizzi, M. G. Bertolini, and G. Scano
Mechanism of CO2 Retention in Patients With Neuromuscular Disease
Chest, February 1, 2000; 117(2): 447 - 453.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by the American College of Chest Physicians.