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Chest, Vol 97, 901-905, Copyright © 1990 by American College of Chest Physicians

ARTICLES

Acute respiratory and cardiovascular effects of inhaled ketanserin in chronic obstructive pulmonary disease. A comparative study with intravenously administered ketanserin

M Cazzola, E Guidetti, J Sepe, G Assogna, G Lucchetti, G Santangelo and G D'Amato
Division of Occupational Pulmonary Disease and Respiratory Allergy, A. Cardarelli Hospital, Naples, Italy.

In a double-blind, crossover study, nebulized ketanserin, a 5-HT2 receptor antagonist, and a placebo were given to eight patients with moderate to severe nonasthmatic COPD. Intravenous ketanserin had rapid onset of action and induced a longer lasting bronchial response than inhaled ketanserin. These results confirm that ketanserin acts as a mild bronchodilator in patients with COPD and demonstrate that the inhaled route has no advantage over the intravenous route in terms of effectiveness. Thus, 5-HT may play a role in bronchomotor tone, at least in patients with chronic airway obstruction.


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