Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lin, C. Y.
Right arrow Articles by Chen, W. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lin, C. Y.
Right arrow Articles by Chen, W. P.

Chest, Vol 97, 1408-1411, Copyright © 1990 by American College of Chest Physicians

ARTICLES

A study of the relationship between childhood nephrotic syndrome and allergic diseases

CY Lin, BH Lee, CC Lin and WP Chen
Department of Medical Research Veterans General Hospital, Taipei, Taiwan, Republic of China.

The incidence of atopic diseases in 206 children with nephrotic syndrome (NS) was studied. Boys with NS had three times higher incidence of bronchial asthma than the general population. There was no difference in the girls. Both boys and girls with NS had about three times more allergic rhinitis and ten times more atopic dermatitis than the general population. In NS patients with associated allergic disease, skin test and allergen-specific IgE antibodies by radioallergosorbent test (RAST) were performed. Most of the patients with dust mites (Dermatophagoides pteronyssinus, Dermatophagoides farinae), egg white, or cow's milk protein-specific antibodies had positive skin tests. One hundred of the 206 children with NS received renal biopsies and serum IgE levels were measured. During the acute nephrotic phase the geometric mean serum IgE levels in minimal change nephrotic syndrome (MCNS), IgM mesangial nephropathy (IgMN), hepatitis B virus-associated membranous nephropathy, and treatment-responsive focal segmental glomerular sclerosis patients were all significantly elevated, in descending order of significance. These high serum IgE levels decreased in remission of NS and elevated again during relapse. The relationship between high serum IgE levels in NS patients and the incidence of allergic diseases showed that one third to one fourth of either IgMN or MCNS patients developed allergic diseases. These results suggest that NS patients had a higher allergic disease incidence. Serum IgE level may serve as one of the prognostic factors. However, an increase in the IgE level may be a reflection of body immunoregulatory imbalance that plays a direct pathogenic role in the occurrence of NS and proteinuria.


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
J. G. VAN DEN BERG, J. ATEN, M. A. CHAND, N. CLAESSEN, L. DIJKINK, J. WIJDENES, F. G. LAKKIS, and J. J. WEENING
Interleukin-4 and Interleukin- 13 Act on Glomerular Visceral Epithelial Cells
J. Am. Soc. Nephrol., March 1, 2000; 11(3): 413 - 422.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H.-K. YAP, W. CHEUNG, B. MURUGASU, S.-K. SIM, C.-C. SEAH, and S. C. JORDAN
Th1 and Th2 Cytokine mRNA Profiles in Childhood Nephrotic Syndrome: Evidence for Increased IL-13 mRNA Expression inRelapse
J. Am. Soc. Nephrol., March 1, 1999; 10(3): 529 - 537.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by the American College of Chest Physicians.