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Chest, Vol 98, 497-499, Copyright © 1990 by American College of Chest Physicians

ARTICLES

Life-threatening bleomycin pulmonary toxicity with ultimate reversibility

LC Hartmann, S Frytak, RL Richardson, DT Coles and RE Cupps
Department of Medical Oncology, Mayo Clinic, Rochester, MN.

A 60-year-old man with advanced seminoma was treated with four cycles of a cisplatin, etoposide and bleomycin. He then developed severe pulmonary toxicity with diffuse infiltrates as evidenced on a chest x- ray film. The room air PaO2 value was 32 mm Hg. The patient was treated with steroids and oxygen supplementation, including a high FIo2 for several days, and survived and eventually experienced marked improvement in his pulmonary status. Aggressive management of severe bleomycin-induced pneumonitis appears justified.


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