Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nishimura, Y.
Right arrow Articles by Fukuzaki, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nishimura, Y.
Right arrow Articles by Fukuzaki, H.

Chest, Vol 98, 1085-1090, Copyright © 1990 by American College of Chest Physicians

ARTICLES

Bronchial hyperreactivity in patients with mitral valve disease

Y Nishimura, H Maeda, M Yokoyama and H Fukuzaki
First Department of Internal Medicine, Kobe University School of Medicine, Japan.

To elicit the mechanism of bronchial hyperreactivity (BHR) in chronic heart failure (CHF), a methacholine inhalation test, pulmonary function test, and cardiac catheterization were performed in 19 patients with mitral valve disease (MVD), and the change of severity of BHR before and after mitral valve replacement (MVR) was also examined in seven of 19 patients with MVD. Sixteen of 19 patients with MVD showed significant increase in respiratory resistance in methacholine inhalation test, while all normal subjects did not. The maximal expiratory flow at 25 percent of vital capacity (Vmax25), a parameter of small airway disease, correlated significantly with log cumulative dose producing a 35 percent decrease in respiratory conductance (PD35Grs) (r = 0.536) and the duration of symptoms (r = -0.682). There was a significant correlation between log PD35Grs and mean pulmonary artery wedge pressure (r = -0.466). After MVR, log PD35Grs was significantly improved in all seven operated-on patients, although six patients retained BHR. We conclude that patients with long-term MVD have marked BHR and that BHR in long-term MVD is related to peripheral airway narrowing with organic remodeling, which was not ameliorated with MVR procedure, in addition to pulmonary congestion.


This article has been cited by other articles:


Home page
 ChestHome page
J. A. Gomez-Hospital, A. Cequier, P. V. Romero, C. Canete, C. Ugartemendia, E. Iraculis, and E. Esplugas
Persistence of Lung Function Abnormalities Despite Sustained Success of Percutaneous Mitral Valvotomy: The Need for an Early Indication
Chest, January 1, 2005; 127(1): 40 - 46.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. A. Gomez-Hospital, A. Cequier, P. V. Romero, C. Canete, C. Ugartemendia, J. Mauri, and E. Esplugas
Partial Improvement in Pulmonary Function After Successful Percutaneous Balloon Mitral Valvotomy
Chest, March 1, 2000; 117(3): 643 - 648.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Gulec, F. Ertas, E. Tutar, Y. Demirel, R. Karaoguz, K. Omurlu, and D. Oral
Bronchial Hyperreactivity in Patients With Mitral Stenosis Before and After Successful Percutaneous Mitral Balloon Valvulotomy*
Chest, December 1, 1999; 116(6): 1582 - 1586.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1990 by the American College of Chest Physicians.