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Chest, Vol 98, 1125-1129, Copyright © 1990 by American College of Chest Physicians

ARTICLES

Serum concentration of soluble interleukin-2 receptor as a sensitive parameter of disease activity in sarcoidosis

N Keicho, K Kitamura, F Takaku and H Yotsumoto
Third Department of Internal Medicine, University of Tokyo, Japan.

We investigated the clinical value of measuring serum concentrations of soluble IL-2R in monitoring sarcoidosis. Serum concentrations of soluble IL-2R were measured in 70 patients with sarcoidosis. The mean value for active untreated sarcoidosis was 1,143 +/- 509 U/ml, while the normal range in 97 healthy control subjects was 80 to 300 U/ml. The mean value for active untreated sarcoidosis was significantly higher than that for dormant disease (353 +/- 183 U/ml) or that for corticosteroid-treated patients (380 +/- 151 U/ml). Serial changes in serum soluble IL-2R level were studied in cases of spontaneous remission or in corticosteroid-treated patients; a good correlation was noted between the changes in serum level of soluble IL-2R and clinical status. A positive correlation was noted between serum concentration of soluble IL-2R and serum ACE activity. These data confirmed that measurement of serum concentration of soluble IL-2R could be used in monitoring the disease activity in sarcoidosis.


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J. C. Grutters, J.-M. Fellrath, L. Mulder, R. Janssen, J. M. M. van den Bosch, and H. van Velzen-Blad
Serum Soluble Interleukin-2 Receptor Measurement in Patients With Sarcoidosis: A Clinical Evaluation
Chest, July 1, 2003; 124(1): 186 - 195.
[Abstract] [Full Text] [PDF]

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 Am. J. Respir. Crit. Care Med.Home page
M. W. ZIEGENHAGEN, U. K. BENNER, G. ZISSEL, P. ZABEL, M. SCHLAAK, and J. MÜLLER-QUERNHEIM
Sarcoidosis: TNF-alpha Release from Alveolar Macrophages and Serum Level of sIL-2R Are Prognostic Markers
Am. J. Respir. Crit. Care Med., November 1, 1997; 156(5): 1586 - 1592.
[Abstract] [Full Text]


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