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Chest, Vol 99, 1197-1202, Copyright © 1991 by American College of Chest Physicians

ARTICLES

Ammonium ion and the anaerobic threshold in man

DM Systrom, CV Fragoso, DJ Kanarek and H Kazemi
Pulmonary and Critical Care Unit (Medical Services), Massachusetts General Hospital, Harvard Medical School, Boston 02114.

To determine if ammonium ion plays a role in the lactate and ventilatory thresholds of incremental exercise, we investigated the effects on blood lactate and ventilation of NH(4+)-buffering by monosodium glutamate. Six normal volunteers underwent intravenous loading with MSG, 9 g, in a randomized, double-blind, saline placebo controlled crossover study. Four of the six subjects had a greater than 10 percent fall in peak (NH4+) following MSG (37 +/- 2.0 vs 25 +/- 4.3 micrograms/dl p = 0.003, PLB vs MSG). When MSG blunted the rise in venous (NH4+) during exercise, uncoupling of the LT and VT was observed. Specifically, with suppression of peak exercise (NH4+) by MSG, the LT was delayed (r = -0.84, p = 0.03), the VT was earlier (r = 0.86, p = 0.02), and the VO2 difference between the LT and VT widened (r = -0.90, p = 0.02). We conclude that NH4+ plays a role in determining the LT and VT of incremental exercise and that the VT may not be exclusively dependent on blood lactate.


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M. Mourtzakis and T. E. Graham
Glutamate ingestion and its effects at rest and during exercise in humans
J Appl Physiol, October 1, 2002; 93(4): 1251 - 1259.
[Abstract] [Full Text] [PDF]


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Copyright © 1991 by the American College of Chest Physicians.