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Chest, Vol 99, 1374-1377, Copyright © 1991 by American College of Chest Physicians

ARTICLES

Caffeine consumption decreases the response to bronchoprovocation challenge with dry gas hyperventilation

P Duffy and YY Phillips
Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307-5000.

OBJECTIVE: To determine whether caffeine consumption affects bronchoprovocation challenge (BPC). DESIGN: A prospective, double- blind, placebo-controlled, randomized, crossover trial. PATIENTS: Eleven nonsmoking men, aged 18 to 42 years, with normal baseline spirometry and evidence of exercise-induced bronchospasm. INTERVENTION: On three separate test days, each individual received, in random order, either placebo, 5 mg/kg caffeine, or 10 mg/kg caffeine, and then underwent BPC with eucapnic voluntary hyperventilation (EVH). RESULTS: Caffeine (10 mg/kg) significantly reduced bronchoconstriction compared to placebo (p = 0.02). The reduction in bronchoconstriction correlated with the serum level of caffeine (p = 0.014). CONCLUSIONS: Caffeine decreases bronchoconstriction due to EVH. Caffeine should be eliminated from diet prior to BPC.




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Copyright © 1991 by the American College of Chest Physicians.