Sampling Time (n = 4) Plasma, µg/mL ELF, µg/mL AMs, µg/mL Levofloxacin 500 mg Levofloxacin 750 mg Ciprofloxacin 500 mg Levofloxacin 500 mg Levofloxacin 750 mg Ciprofloxacin 500 mg Levofloxacin 500 mg Levofloxacin 750 mg Ciprofloxacin 500 mg 4 h 5.29 ± 1.23 11.98 ± 2.99 § 2.11 ± 0.35 9.94 ± 2.74 ** 22.12 ± 14.92 1.87 ± 0.91 97.9 ± 80.0|| ¶ # 105.1 ± 65.5¶ # 34.9 ± 23.2¶ # 12 h 3.07 ± 0.93 4.06 ± 0.51 0.55 ± 0.09 6.46 ± 2.48 ** 9.17 ± 5.34 0.41 ± 0.10 36.7 ± 23.4 ¶ # 36.2 ± 26.1 ¶ # 6.8 ± 5.9|| ¶ # 24 h 0.60 ± 0.10 1.69 ± 1.14 0.08 ± 0.03 0.70 ± 0.40 1.45 ± 0.75 § 0.0** 13.8 ± 16.0|| ¶ # 15.1 ± 2.0 ¶ # 2.3 ± 2.8 #

^* Data are expressed as mean ± SD.

Differences in levofloxacin, 500 mg, and ciprofloxacin, 500 mg, were significant (p < 0.05) during this sampling time of the same body fluid.

Differences in levofloxacin, 750 mg, and ciprofloxacin, 500 mg, were significant (p < 0.05) during this sampling time of the same body fluid.

^§ Differences in levofloxacin, 750 mg, and levofloxacin, 500 mg, were significant (p < 0.05) during this sampling time of the same body fluid.

^|| Three of four subjects had adequate samples available for drug assay.

^¶ Differences in AMs and plasma were significant (p < 0.05) during this sampling time for the same drug regimen.

^# Differences in AMs and ELF were significant (p < 0.05) during this sampling time for the same drug regimen.

^** Differences in ELF and plasma were significant (p < 0.05) during this sampling time for the same drug regimen.

None of four subjects had concentrations equal to or above the quantitative limit of detection.

Three of four subjects had concentrations equal to or above the quantitative limit of detection.

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