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(Chest. 2002;121:825-830.)
© 2002 American College of Chest Physicians

Clinical Significance of Pleural Effusion in Acute Aortic Dissection*

Noritake Hata, MD; Keiji Tanaka, MD; Takahiro Imaizumi, MD; Toshihiko Ohara, MD; Takayoshi Ohba, MD; Takurou Shinada, MD and Teruo Takano, MD

* From the Intensive Care Unit (Drs. Hata, Imaizumi, Ohara, Ohba, and Shinada), Chiba Hokusoh Hospital, Nippon Medical School, Chiba; and Department of Internal Medicine (Drs. Tanaka and Takano), Nippon Medical School, Tokyo, Japan.

Correspondence to: Noritake Hata, MD, Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, 1715 Kamagari, Inbamura, Inbagun, Chiba 270-1694, Japan;


   Abstract
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 Abstract
Introduction
 Materials and Methods
 Results
 Discussion
 References
 
Study objective: To clarify the clinical significance of pleural effusion in the clinical course of acute aortic dissection (AAD).

Design: Retrospective clinical series.

Setting: A university hospital.

Patients: Fifty-five patients strongly suspected of having AAD because of severe chest or back pain. Patients with obvious ischemic heart disease, lung disease, and pleural disease were excluded.

Interventions: An additional diagnosis of pleural effusion was made when evident by CT.

Measurements and results: Pleural effusion was detected in 42 of 48 patients (88%) with AAD (mean ± SD age, 65 ± 12 years; 35 men and 13 women), but in only 1 of 7 patients (14%) who proved not to have AAD (mean age, 74 ± 10 years; 6 men and 1 woman). Effusion appeared at a mean of 4.5 days after onset of dissection. Thoracentesis performed in six patients showed a bloody effusion in three patients and an exudative effusion in three patients. In the six AAD patients without pleural effusion, four patients underwent surgery within 3 days after onset of dissection. In patients with AAD, effusion was demonstrated on the first CT after hospital admission in 18 patients, and was bilateral in 32 patients. WBC count in blood, serum C-reactive protein concentration, and body temperature were higher in patients with effusion (13,400 ± 3,600/µL, 18.4 ± 11.5 mg/dL, and 38.2 ± 0.7°C) than in those without effusion (10,300 ± 2,900/µL, 4.5 ± 4.2 mg/dL, and 37.0 ± 1.0°C, respectively).

Conclusions: Pleural effusion occurs frequently in patients with AAD, often in association with inflammatory reactions.

Key Words: acute aortic dissection • CT • inflammatory reaction • pathogenesis • pleural effusion


   Introduction
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 Abstract
 Introduction
Materials and Methods
 Results
 Discussion
 References
 
Pleural effusion occurs in various diseases and is an important cause of respiratory dysfunction. Even when not present on initial chest radiography and CT, pleural effusion may appear in patients with acute aortic dissection (AAD), sometimes several days after the onset of dissection. In rare cases, pleural effusion or hemothorax, rather than chest or back pain, is the first sign of AAD.1 2 The pathogenesis of pleural effusion has been investigated in inflammatory conditions, including tuberculosis, other bacterial and viral infections, and trauma, as well as in neoplasia.3 4 5 6 7 8 9 10 11 However, few reports have considered the frequency and pathogenesis of pleural effusion occurring during the clinical course of AAD.12 13 14 The aim of this study was to clarify the clinical significance of pleural effusion in patients with AAD, and to investigate the relationship of these effusions to associated clinical events including inflammatory reactions. We evaluated CT and other findings in patients with presumptive diagnoses of AAD.


   Materials and Methods
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 Abstract
 Introduction
 Materials and Methods
Results
 Discussion
 References
 
Of 1,580 patients admitted to the ICU at our hospital between January 1994 and August 2000, a total of 55 patients strongly suspected of having AAD were studied retrospectively. Forty-eight patients were confirmed to have AAD; chronic aortic dissection was diagnosed in 3 other patients; aneurysm with no dissection was diagnosed in 2 patients; pleuritis was diagnosed in 1 patient; and pain of undefined origin was diagnosed in 1 patient (Fig 1 ). The diagnosis of AAD was made based on typical chest and back pain and findings on chest radiography, CT, and aortography. CT was performed every 3 to 5 days to reassess the aortic dissection for possible extension.15 Extension of aortic dissection, appearance of complicating pulmonary disorders, and pleural effusion on serial CT were evaluated by multiple intensivists and radiologists. Radiographic measurement of the pleural effusion was not performed. When the effusion was massive and compromised respiratory function, thoracentesis was performed to evacuate the effusion, and laboratory analysis of pleural fluid was carried out. We sought to determine how frequently and when in the course of AAD pleural effusion occurred. Relationships were evaluated between pleural effusion and various clinical features, including age, gender, site of aortic dissection according to DeBakey et al16 and Stanford classifications,17 inflammatory markers (body temperature, WBC count, and C-reactive protein), and clinical outcome. Body temperature, WBC count, and C-reactive protein ordinarily were measured daily for at least 14 days after hospital admission. However, in patients undergoing surgery, reassessment of pleural effusions and inflammatory markers were discontinued after surgery.



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  		Figure 1.. Of 1,580 patients admitted to an ICU, 55 were strongly suspected of having AAD. After imaging studies, AAD was diagnosed in 48 patients. Pleural effusion was demonstrated in 42 of these 48 patients.

 
Values are expressed as the mean ± SD. Statistical analyses were performed by one-way analysis of variance and the {chi} test. A p value < 0.05 was chosen to indicate statistical significance.


   Results
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 Abstract
 Introduction
 Materials and Methods
 Results
Discussion
 References
 
Characteristics of Patients
Clinical findings in 48 patients with AAD and 7 patients who proved not to have AAD are presented in Table 1 . Differences in age and gender ratio between patients with AAD and those with other diagnoses did not achieve statistical significance. In the group with AAD, 11 patients underwent surgery; 8 patients had Stanford type-A dissections with cardiac and/or cerebral damage, and 3 patients had type-B dissections with impending rupture. The presence of pleural effusion was not an indication for surgery. Twelve patients died during hospitalization, including some deaths in the postoperative period. Of patients without AAD, no patients underwent surgery and two patients died. One patient with AAD was transferred to another hospital 49 days after onset of AAD.


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  		Table 1.. Characteristics of Patients With Suspected AAD*

 
Occurrence of Pleural Effusion
Pleural effusion was detected at various times after hospital admission in 42 of 48 patients (87.5%) with AAD, but in only 1 of 7 patients (14.3%) without AAD. Pleural effusion appeared 4.5 ± 3.9 days after the onset of AAD (range, 1 to 15 days; Fig 2 ). Effusion was seen on hospital day 1 in 18 patients. However, 3 of these patients were admitted to our hospital >= 2 days after the onset of AAD, so pleural effusion was detected on the first day of dissection in only 15 patients. None had massive hemothorax following rupture of an aneurysm. Pleural effusion resolved before discharge from the hospital (42.2 ± 20.1 days after onset of dissection) in 22 patients with AAD. In six other patients with AAD, the effusion persisted at discharge from the hospital. In 14 patients with AAD, reevaluations of the pleural effusion were interrupted by death in 8 patients, surgery in 5 patients, and transfer to another hospital in 1 patient. Characteristics of the 48 patients with AAD with or without pleural effusion are shown in Table 2 . No significant difference was noted in age, gender ratio, or category of dissection (Stanford and DeBakey classification). Of the six patients with AAD but no pleural effusion, four patients underwent surgery within 3 days after onset of AAD; two of these patients died after surgery.



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  		Figure 2.. Pleural effusion in patients with AAD was apparent on the day of onset in 15 patients. Of 42 patients, pleural effusion was detected within 3 days in 22 patients and within 1 week in 34 patients. On average, effusion was apparent 4.5 ± 3.9 days after the onset of AAD.

 

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  		Table 2.. Characteristics of Patients With Proven AAD*

 
Characteristics of Pleural Effusion
In patients with AAD, effusion was bilateral in 31 patients (73.8%) and left sided in 11 other patients (26.2%). Thoracentesis was performed in six patients because of a compromised respiratory state from a massive pleural effusion. The effusion was bloody in three patients and exudative in three patients (Table 3 ).


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  		Table 3.. Characteristics of Pleural Effusion in Patients With AAD*

 
Relationship Between Effusion and Inflammatory Reaction
Inflammatory responses, including maximum WBC count, maximum body temperature, and maximum serum concentration of C-reactive protein, are shown in Figure 3 . The WBC count of patients with AAD and pleural effusion was 13,359 ± 3,588/µL, somewhat higher than in patients with AAD without pleural effusion (10,294 ± 2,863/µL; difference not significant) and higher than patients without AAD (9,803 ± 2,136/µL; p < 0.05). Body temperature was 38.2 ± 0.7°C in AAD patients with pleural effusion, 37.0 ± 1.0°C in AAD patients without pleural effusion, and 37.2 ± 0.7°C in the other patients, being significantly higher in AAD dissection patients with pleural effusion than in those without effusion. C-reactive protein was 18.4 ± 11.5 mg/dL in AAD patients with pleural effusion, significantly higher than in AAD without pleural effusion (4.5 ± 4.2 mg/dL) or in other patients (5.6 ± 4.4 mg/dL).



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  		Figure 3.. Maximum WBC count, maximum body temperature (BT), and C-reactive protein (CRP) concentration recorded during the hospital course of patients with both AAD and pleural effusion (black), AAD patients without pleural effusion (white), and patients who proved not to have AAD (gray). WBC count, body temperature, and C-reactive protein levels were higher in AAD patients with pleural effusion than in those without pleural effusion. *p < 0.05 vs patients with pleural effusion without AAD and those with AAF and pleural effusion.

 

   Discussion
TOP
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
References
 
Pleural effusion was demonstrated by CT in most of our patients with AAD (87.5%). Four of the six patients with no occurrence of pleural effusion became candidates for surgery within 2 days after dissection onset. Given that the average time of appearance of pleural effusion on CT was 4.5 days after the onset of AAD, pleural effusion might have developed had surgery not been performed. Hasegawa et al18 found pleural effusions in eight of nine AAD patients with respiratory failure. In our study, we investigated the occurrence of pleural effusion in patients with AAD without regard to respiratory failure, and pleural effusion still was frequent.

Other authors have found effusion to be less common. Maffei et al12 reported finding pleural effusion by CT in only 4 of 44 patients with treated AAD; the acute period of aortic dissection was not studied. Our patients were followed up for > 1 month after onset of AAD. Of the 42 patients with pleural effusion, effusion resolved during the month following onset in 22 patients. Eight of the remaining 20 patients died in the hospital, 5 patients underwent surgery, and 1 patient was transferred to another hospital before confirmation of disappearance of the effusion. Pleural effusion persisted in only six patients at discharge from the hospital.

Mechanisms underlying occurrence of pleural effusion have been investigated in cases of infectious disease and of neoplasm. Participation of inflammatory cytokines such as interleukin (IL)-6, IL-8, IL-10, vascular endothelial growth factor, and tumor necrosis factor-{alpha} has received considerable recent attention.3 4 5 6 7 8 9 10 11 While cytokine participation in pleural effusion development in patients with AAD is not clear, some investigators have reported possible associations with inflammatory reactions. Hasegawa et al18 suggested that leucocytosis, high body temperature, thrombocytosis, and elevation of IL-8 were related to AAD and pleural effusion. The results of our study support their suggestion. Schattner et al,19 Veyssier-Belot et al,20 Giladi et al,21 and Murray et al22 reported occurrence of pleural effusion and prolonged fever in some of their patients with chronic aortic dissection.

In rupture of AAD, hemothorax or bloody pleural effusion typically are seen, though occurrence of painless hemorrhagic pleural effusion in patients with AAD also has been reported by several investigators.1 2 In our study, thoracentesis in six patients demonstrated hemorrhagic effusion in three patients and a nonhemorrhagic exudate in three patients.

When Teasell and Dittmer23 reported various complications of long-term bed rest, atelectasis and pneumonia were frequent. Cuvelier and Riquet24 suggested that pleural effusion can occur secondarily to atelectasis. Bed rest is prescribed for patients with AAD to prevent extension of aortic dissection and to control BP. Pleural effusion therefore might have complicated bed rest in some of our patients. However, in 18 patients, the effusion was present on the day of dissection onset; on average, effusions appeared 4.5 days after onset. Effusion apparently resulted from long-term bed rest in only a few of our patients.

Mattison et al25 reported the frequency of pleural effusion and underlying diseases in an ICU. In their report, effusion was seen in 62% of patients; underlying diseases were congestive heart failure (35%), atelectasis (23%), pneumonia (11%), and various others (31%), including liver dysfunction, cancer, pancreatitis, uremia, and empyema. Pleural effusion associated with AAD was not included in their cases. Notably, these authors studied only 100 patients overall. In our study, 1,580 patients treated in an ICU were evaluated, yielding 48 confirmed cases of dissection.

In conclusion, pleural effusion was frequent in patients with AAD (87.5%) but rare in patients strongly suspected of having AAD who proved to have a different condition. Occurrence of pleural effusion followed onset of AAD by mean of 4.5 days. Pleural effusion demonstrated by serial CT was a common finding in patients with AAD, and also is recognized for altered mental status, ECG changes, aortic insufficiency, loss of pulses, and intractable pain. Evaluation for pleural effusion is highly important in the diagnosis and treatment of aortic dissection and other diseases with chest pain.


   Footnotes
 
Abbreviations: AAD = acute aortic dissection; IL = interleukin

The work was performed at Chiba Hokusoh Hospital.

Received for publication February 13, 2001. Accepted for publication August 29, 2001.


   References
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 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
 References
 

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