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Jeddah, Saudi Arabia
Ottowa, Canada
Dr. Kinsara is Staff Cardiologist, Jeddah National Guard Hospital, Jeddah, Saudi Arabia. Dr. Chan is Professor of Medicine, University of Ottawa, Ottawa, Canada.
Correspondence to: Kwan-Leung Chan, MD, University of Ottowa Heart Institute, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada; e-mail: kchan{at}ottowaheart.ca
Coarctation of the aorta is characterized by narrowing of the aorta just distal to the left subclavian artery. It has a male preponderance and is frequently associated with hypoplasia of the aortic arch and isthmus. Other associated conditions include bicuspid aortic valve, dilated aortic root, mitral valve abnormalities, and intracranial aneurysm.12 Bicuspid aortic valve is the most common associated lesion occurring in about half of the patients. Coarctation of the aorta imposes a pressure load on the left ventricle, resulting in proximal systemic hypertension that may persist after surgery if correction is performed beyond 5 years of age.3 Patients who have surgical correction for coarctation are at risk for long-term complications including death.145 There were 87 late deaths, with a mean age of death of 38 years in 646 such patients followed up at the Mayo Clinic. The most common cause of death was coronary artery disease, followed by sudden death, heart failure, stroke, and ruptured aortic aneurysm.5 Regular follow-up with aggressive treatment of risk factors for coronary artery disease is clearly necessary in these patients.
There are several surgical procedures for aortic coarctation, including resection with end-to-end anastomosis, resection with replacement by a tube graft, patch angioplasty, and bypass grafts. There is increasing interest in the endovascular management of coarctation by angioplasty alone or with stenting, particularly in adult patients with this condition.678 This approach has the advantage that it can be performed by the percutaneous approach and can potentially avoid some of the serious complications associated with surgery.8 Residual abnormalities of the aorta both at the site of coarctation repair and elsewhere are common in patients who have undergone either surgery or percutaneous dilatation.45678 Recoarctation can occur such that 15% of patients require repeat intervention in 5 years.4 Aortic aneurysm at the site of the surgical repair occurs in up to 5% of patients after surgical repair, and is also a significant complication in patients who have undergone percutaneous angioplasty.45678 The development of recoarctation and aneurysm formation increases the risk of serious complications such as aortic dissection and rupture.5 Thus, these patients not only need comprehensive and regular follow-up to optimize the management of hypertension and other risk factors for coronary artery disease, but they also require long-term follow-up for aortic complications such as recoarctation and aneurysm formation.
Different noninvasive imaging modalities can be used in the assessment and follow-up of patients with native or repaired coarctation, and the advantages and limitations of echocardiography (transthoracic and transesophageal), CT, and MRI are summarized in Table 1 . Transthoracic echocardiography is ideal for the initial assessment, since it provides comprehensive assessment of valvular and ventricular function, in addition to reliable assessment of the pressure gradient across the coarctation. It is widely available, although technical skill is required to obtain optimal velocity profile across the coarctation to calculate the pressure gradient.
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High-resolution images of the entire aorta including the coarctation segment can be obtained by MRI, which provides detailed anatomic information for the planning of invasive intervention such as surgery or percutaneous angioplasty. By virtue of its ability to provide multiple oblique-sagittal planes of the aorta, MRI is particularly suited in the follow-up of patients who have undergone surgical repair for coarctation, since the aortic arch and proximal descending aorta in these patients tend to be tortuous and difficult to image in the proper long axis view.11 However, there are situations where MRI is not the imaging modality of choice. One obvious situation is in patients who cannot undergo MRI because they have metallic prostheses such as pacemakers. Optimal images cannot be obtained in patients who have had treatment with endovascular stents since the stent artifact generally obscures the aortic segment that has been stented. In these patients the location and morphology of the stent can best be assessed by using both CT and TEE. CT is less affected by the stent artifact and can provide high-resolution images in the transverse plane. Compared to MRI, the aortic arch is not as well seen by CT because it is imaged obliquely and reconstructed CT sagittal views have limited resolution.
Although both MRI and CT can give high-quality images, measurements of the aorta by MRI and CT are not interchangeable. In this issue of CHEST (see page 1169), Hager et al showed that the differences between the two techniques in aortic measurements can be as large as 9 mm. This is an important message to bear in mind when assessing for progression of aortic dilatation in patients with Marfan syndrome, repaired coarctation, or chronic aortic dissection. Ideally, only serial measurements by the same method should be compared to minimize variability, and even then it is important to be aware of the intraobserver and interobserver variabilities of the specific technique (whether it is echocardiography, MRI, or CT) in one’s own institution. We need to avoid basing management decision on "measurements of different investigators on different studies with perhaps different methods."
Patients with native and repaired coarctation are at risk for long-term complications and require regular follow-up. Understanding the advantages and limitations of the noninvasive imaging modalities should lead to their proper use and result in an improved long-term outcome for these patients.
References
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